Study to Allow Access to Pasireotide for Patients Benefiting From Pasireotide Treatment in Novartis-sponsored Studies

Completed · Phase 4

Conditions studied: Cushing's Disease, Acromegaly, Neuroendocrine Tumors, Pituitary Tumors, Ectopic ACTH Secreting (EAS) Tumors, Dumping Syndrome, Prostate Cancer, Melanoma Negative for bRAF, Melanoma Negative for nRAS

In brief

The purpose of this study is to allow continued use of pasireotide in patients who are on pasireotide treatment in a Novartis-sponsored study and are benefiting from the treatment as judged by the investigator.

Key facts

Study ID: NCT01794793
Run by: RECORDATI GROUP
People needed: 337
Starts: 2013-06-10
Expected to finish: 2023-07-25
Last updated by the study team: 2024-10-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Patient is currently participating in a Novartis-sponsored study receiving pasireotide (LAR and/or s.c.) on monotherapy or combination therapy (for Cushing's Disease or Acromegaly), and has fulfilled all required assessments in the parent study and patients that are benefiting from the study treatment have no other alternatives.
Patient is currently benefiting from the treatment with pasireotide, as determined by the investigator
Patient has demonstrated compliance, as assessed by the investigator, with the parent study requirements.
Willingness and ability to comply with scheduled visits, treatment plans and any other study procedures.
Written informed consent obtained prior to enrolling in roll-over study and receiving study medication.
If consent cannot be expressed in writing, it must be formally documented and witnessed, ideally via an independent trusted witness.

You may not qualify if…

Patient has been permanently discontinued from pasireotide study treatment in the parent study due to unacceptable toxicity, non-compliance to study procedures, withdrawal of consent or any other reason.
Pregnant or nursing (lactating) women, where pregnancy is defined as the state of a female after conception and until the termination of gestation, confirmed by a positive hCG laboratory test.
Women of child-bearing potential, defined as all women physiologically capable of becoming pregnant, unless they are using highly effective methods of contraception during the study treatment and for 30 days after the final dose of pasireotide s.c. and 84 days after the final dose of pasireotide LAR. Highly effective contraception is defined as either:
Total abstinence (when this is in line with the preferred and usual lifestyle of the patient. Periodic abstinence (e.g., calendar, ovulation, symptothermal, post-ovulation methods) and withdrawal are not acceptable methods of contraception
Female sterilization (have had surgical bilateral oophorectomy with or without hysterectomy) or tubal ligation at least six weeks before taking study treatment. In case of oophorectomy alone, only when the reproductive status of the woman has been confirmed by follow up hormone level assessment.
Male sterilization (at least 6 months prior to enrolling). For female patients on the study the vasectomized male partner should be the sole partner for that patient.
Use of oral, injected or implanted hormonal methods of contraception or placement of an intrauterine device (IUD) or intrauterine system (IUS), or other forms of hormonal contraception that have comparable efficacy (failure rate <1%), for example hormone vaginal ring or transdermal hormone contraception.
In case of use of oral contraception women should have been stable on the same pill for a minimum of 3 months before taking study treatment.
Women are considered post-menopausal and not of child bearing potential if they have had 12 months of natural (spontaneous) amenorrhea with an appropriate clinical profile (i.e. age appropriate, history of vasomotor symptoms) or have had surgical bilateral oophorectomy (with or without hysterectomy), total hysterectomy, or tubal ligation at least six weeks ago. In the case of oophorectomy alone, only when the reproductive status of the woman has been confirmed by follow up hormone level assessment is she considered not of child-bearing potential.
Sexually active males, unless they use a condom during intercourse while taking drug and for 1 months after pasireotide s.c. last dose and 3 months after pasireotide LAR last dose, should not father a child in this period. A condom is required to be used also by vasectomized men in order to prevent delivery of the drug via seminal fluid.

Where it is running

Cedars Sinai Medical Center Cedars Sinai 4 — Los Angeles, California, United States
Stanford Universtiy Medical Center Stanford Hospital & Clinics — Stanford, California, United States
University of Michigan Comprehensive Cancer Center SC-2 — Ann Arbor, Michigan, United States
Memorial Sloan-Kettering Cancer Center SC — New York, New York, United States
Virginia Endocrinology Research SC — Chesapeake, Virginia, United States
Swedish Cancer Institute Swedish Cancer Institute (SC) — Seattle, Washington, United States
Recordati Investigative Site — CABA, Buenos Aires, Argentina
Recordati Investigative Site — Mar del Plata, Buenos Aires, Argentina
Recordati Investigative Site — Edegem, Antwerpen, Belgium
Recordati Investigative Site — Bruges, Belgium
Recordati Investigative Site — Brussels, Belgium
Recordati Investigative Site — Brussels, Belgium
Recordati Investigative Site — Ghent, Belgium
Recordati Investigative Site — Leuven, Belgium
Recordati Investigative Site — Liège, Belgium
Recordati Investigative Site — Wilrijk, Belgium
Recordati Investigative Site — Fortaleza, Ceará, Brazil
Recordati Investigative Site — Curitiba, Paraná, Brazil
Recordati Investigative Site — Rio de Janeiro, Rio de Janeiro, Brazil
Recordati Investigative Site — Porto Alegre, Rio Grande do Sul, Brazil
Recordati Investigative Site — Joinville, Santa Catarina, Brazil
Recordati Investigative Site — Botucatu, São Paulo, Brazil
Recordati Investigative Site — São Paulo, São Paulo, Brazil
Recordati Investigative Site — Sofia, Bulgaria
Ximed Research SC - SOM230B2412 — La Jolla, California, United States

Full record on ClinicalTrials.gov

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