Post-traumatic Arthritis Associated With Joint Injury
Completed
Conditions studied: Arthritis
In brief
Arthritis is the nation's most common cause of disability. An estimated 50 million U.S. adults (about 1 in 5) report doctor-diagnosed arthritis. Twenty three million U.S. adults of working age (18-64 years) have arthritis; and in this age group arthritis-attributable work limitations affect about 1 in 3 people. An estimated 12% of all patients seeking intervention for symptomatic arthritis have an etiology of previous trauma to the involved joint. The purpose of this study is to examine these inflammatory compounds in the joint fluid (synovial fluid), the joint lining (synovium), and in blood among subjects with isolated intra-articular fractures. The hypothesis is that early levels of intra-articular inflammation and markers of joint tissue degeneration following articular fracture in the human knee are predictive of the development of PTA (Post Traumatic Arthritis). Early levels of intra-articular inflammation and markers of joint tissue degeneration identified from human knee joints following articular injury are predictive of the development of PTA in the mouse knee. Samples of blood, urine and synovial fluid will be taken at the spanning frame surgery and only synovial fluid at the ORIF (Open Reduction Internal Fixation)surgery. Two MRIs (Magnetic Resonance Imaging) will be part of this study at 4 weeks and 18 months.Participants will complete a set of questionnaires(KOOS: Knee Injury and Osteoarthritis Outcome Score) at 4 weeks and 18 months.
Key facts
- Study ID
- NCT01792791
- Run by
- Duke University
- People needed
- 20
- Starts
- 2012-10-01
- Expected to finish
- 2016-12-01
- Last updated by the study team
- 2016-12-19
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Subjects will be adult patients (over 18 years old)
- Patients must present with a unilateral closed intra-articular fracture of the knee.
You may not qualify if…
- Pre-existing arthritis in the injured or contra-lateral knee,
- Previous total knee replacement
- Active joint infection
- Pathologic fracture
- Active inflammatory arthritis
- Open fracture of the involved knee
- Contra-lateral knee injury
- HIV infection (if previously known)
Where it is running
- Duke University Medical Center — Durham, North Carolina, United States
Full record on ClinicalTrials.gov
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