Improving Depression Outcome by Enhancing Memory for Cognitive Therapy
Completed · Phase 2
Conditions studied: Major Depressive Disorder (MDD)
In brief
Existing drug and talking therapies for major depressive disorder (MDD) fail to produce complete recovery. This study will determine if substantial improvements to one of the most promising therapies, cognitive therapy (CT), can be achieved by administering a carefully designed procedure to improve memory for the content of CT sessions. This is important because (a) memory deficits are common in MDD patients and (b) each CT therapy session typically covers a complex array of topics and various skills are taught.
Key facts
- Study ID
- NCT01790919
- Run by
- University of California, Berkeley
- People needed
- 48
- Starts
- 2013-02-01
- Expected to finish
- 2015-03-01
- Last updated by the study team
- 2015-09-17
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- diagnosis of major depressive disorder (MDD), first episode, recurrent or chronic, according to DSM-IV-TR criteria
- score of 24 or above on the Inventory of Depressive Symptomatology (IDS)-Clinician and 26 or above on the IDS-Self-report
- older than 18 years of age
- if taking medications for mood, medications must be stable for the past 4 weeks
- able and willing to give informed consent
You may not qualify if…
- history of bipolar disorder
- history of psychosis (including schizophrenia, schizophreniform disorder, schizoaffective disorder, delusional disorder, or psychotic organic brain syndrome)
- current non-psychotic Axis I disorder if it constitutes the principal diagnosis and if it requires treatment other than that offered in the project (including anxiety disorders including active PTSD, somatoform disorders, dissociative disorders, or eating disorders, etc.)
- history of substance dependence in the past six months
- IQ below 80
- evidence of any medical disorder or condition that could cause depression or preclude participation in CT
- current suicide risk sufficient to preclude treatment on an outpatient basis
Where it is running
- University of California, Berkeley — Berkeley, California, United States
Full record on ClinicalTrials.gov
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