Effect of a Commonly Used Antibiotic, Doxycycline, in Women With Polycystic Ovarian Syndrome

Completed · Phase 3 · Has a placebo group

Conditions studied: Polycystic Ovarian Syndrome (PCOS), Irregular Menstrual Cycles, Androgen Excess

In brief

The purpose of this study is to study the effect of a commonly used antibiotic, doxycycline, on the production of ovarian hormones and menstrual cycles in women with Polycystic Ovarian Syndrome (PCOS).

Key facts

Study ID

NCT01788215

Run by

University of Rochester

People needed

10

Starts

2010-11-01

Expected to finish

2014-09-01

Last updated by the study team

2016-01-13

Who can join

Age: 18 and older, up to 40. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Women between 18 and 40 years of age.
• History of PCOS with < 8 periods the proceeding year
• Clinical or biochemical evidence of androgen excess
• BMI <40
• Willingness to sign consent for study including participation with collection of blood specimens
• Willingness to discontinue OCP for duration of study period up to 36 weeks

You may not qualify if…

• Pregnancy
• Hypersensitivity to doxycycline or tetracycline
• History of Cushing's syndrome
• History of hyperprolactinemia
• History of congenital adrenal hyperplasia
• Significant hepatic impairment, including serum AST or ALT >1.5 times upper limits of normal.
• Significant renal impairment, GFR <60 ml/min
• Current use of metformin, statins, glucocorticoids, spironolactone and/or anti-estrogens.

Where it is running

• University of Rochester, Strong Fertility Center — Rochester, New York, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.