Nutritional and Functional Changes in Heart Failure and COPD
Completed · Not applicable
Conditions studied: Chronic Heart Failure, Chronic Obstructive Pulmonary Disorder
In brief
Weight loss commonly occurs in patients with chronic heart failure (CHF) and chronic obstructive pulmonary disorder (COPD), negatively influencing their quality of life, treatment response and survival. Loss of muscle protein is generally a central component of weight loss in CHF and COPD patients but patients also have reductions in fat mass and bone density, independent of the severity of the disease state. The purpose of this cross-sectional study is to provide detailed insight in disease related gut function by obtaining information on gut permeability, digestion and absorption of glucose, fat and protein in CHF and COPD patients compared to matched healthy controls. This will provide required information that is necessary to implement new strategies to develop optimal nutritional regimen in CHF and COPD. The hypothesis is that CHF and COPD are related to decreased gut function and absorption, leading to decreased anabolic response. Second, this decreased nutritional status is linked to reduced muscle functioning and possibly decreased cognition. In addition, we will examine the effect of aging on by comparing gut function digestion and absorption of the CHF and COPD aged matched healthy controls to a group of young healthy subjects.
Key facts
- Study ID
- NCT01787682
- Run by
- Texas A&M University
- People needed
- 99
- Starts
- 2012-12-01
- Expected to finish
- 2017-09-17
- Last updated by the study team
- 2022-02-07
Who can join
Age: 20 and older. Sex: any. Healthy volunteers: accepted.
You may not qualify if…
- Any condition that may interfere with the definition 'healthy subject' according to the investigator's judgment (healthy subjects only)
- History of untreated metabolic diseases including hepatic or renal disorder
- Presence of acute illness or metabolically unstable chronic illness
- Presence of fever within the last 3 days
- Body mass index >40 kg/m2 (healthy subjects only)
- Any other condition according to the PI or nurse that was found during the screening visit, that would interfere with the study or safety of the patient
- Use of protein or amino acid containing nutritional supplements within 5 days of first study day
- Current use of long-term oral corticosteroids (CHF only)
- Use of short course of oral corticosteroids within 4 weeks preceding first study day
- Failure to give informed consent or Investigator's uncertainty about the willingness or ability of the subject to comply with the protocol requirements
- (Possible) pregnancy
Where it is running
- Texas A&M University — College Station, Texas, United States
Full record on ClinicalTrials.gov
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