Dairy Fat as a Mediator of Vitamin E Adequacy in Individuals With Metabolic Syndrome
Completed · Not applicable
Conditions studied: Non-alcoholic Fatty Liver, Metabolic Syndrome
In brief
This study is conducted to investigate if vitamin E status in healthy individuals and individuals with metabolic syndrome can be improved by dairy fat. The investigators hypothesize that full-fat dairy will substantially increase the bioavailability of alpha-tocopherol, a form of vitamin E. The results of this study will contribute to the application of dairy fat as a simple and effective strategy for improving vitamin E status, which is partly due to poor vitamin E intake. By completing this study, the investigators anticipate developing new dietary recommendations to achieve adequate vitamin E status through the regular consumption of dairy fat paired with foods containing vitamin E.
Key facts
- Study ID
- NCT01787591
- Run by
- Ohio State University
- People needed
- 21
- Starts
- 2013-04-01
- Expected to finish
- 2015-12-01
- Last updated by the study team
- 2016-11-22
Who can join
Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- specific criteria of the metabolic syndrome: large waist circumference (>102 or >89 cm for men and women, respectively), high fasting triglycerides (150-300 mg/dL), low fasting HDL (<40 and <50 mg/dL for men and women, respectively), high blood pressure (>130/85 mm Hg) and high fasting glucose (110-180 mg/dL)
- BMI: >30 kg/m2,
- non-dietary supplement users for >2-mo
- no use of medications known to affect lipid metabolism
- no history of gastrointestinal disorders
- resting blood pressure <140 mm Hg
- not taking any medications that control hypertension
You may not qualify if…
- lactose-intolerance
- excessive alcohol consumption (>3 drinks/d)
- >5 h/wk of aerobic activity
- women who are pregnant, lactating, or have initiated or changed birth control in the past 3-mo
- plasma alpha-tocopherol >20 μmol/L.
Where it is running
- Ohio State University — Columbus, Ohio, United States
Full record on ClinicalTrials.gov
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