Dose-Ranging Study Of Tofacitinib In Adults With Active Ankylosing Spondylitis

Completed · Phase 2 · Has a placebo group

Conditions studied: Ankylosing Spondylitis

In brief

This is the first study of oral tofacitinib in adults with active ankylosing spondylitis. It is designed to obtain information on the efficacy and safety of 3 different doses of tofacitinib.

Key facts

Study ID

NCT01786668

Run by

Pfizer

People needed

208

Starts

2013-04-01

Expected to finish

2015-03-01

Last updated by the study team

2016-06-10

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Documented diagnosis of Ankylosing Spondylitis
• Has active disease despite concurrent nonsteroidal anti-inflammatory drugs (NSAIDs) treatment or is intolerant to NSAIDs

You may not qualify if…

• Pregnant or lactating females
• Currently receiving or previous use of a Tumor Necrosis Factor (TNF) inhibitor or any biological agent

Where it is running

• Desert Medical Advances — Palm Desert, California, United States
• Arthritis & Rheumatology Associates — Clearwater, Florida, United States
• Millennium Research — Ormond Beach, Florida, United States
• Southwest Florida Clinical Research Center — Tampa, Florida, United States
• Covance Central Laboratory Services,Inc — Indianapolis, Indiana, United States
• Klein & Associates, M.D., P.A. — Hagerstown, Maryland, United States
• Progressive Radiology — Hagerstown, Maryland, United States
• Advanced Medical Imaging (MRI center) — Lincoln, Nebraska, United States
• Arthritis Center of Nebraska (X-ray center) — Lincoln, Nebraska, United States
• Physician Research Collaboration, LLC — Lincoln, Nebraska, United States
• Charlotte Radiology/ Carolina Imaging Services — Ballantyne, North Carolina, United States
• Joint and Muscle Research Institute — Charlotte, North Carolina, United States
• Presbyterian Imaging — Charlotte, North Carolina, United States
• Paramount Medical Research & Consulting, LLC — Middleburg Heights, Ohio, United States
• Premier Physicians Centers — Westlake, Ohio, United States
• Oregon Health & Science University — Portland, Oregon, United States
• Altoona Center for Clinical Research — Duncansville, Pennsylvania, United States
• Clinical Research Center of Reading, LLC — Wyomissing, Pennsylvania, United States
• Investigational Drug Service — Seatle, Washington, United States
• Seattle Rheumatology Associates — Seattle, Washington, United States
• Arthritis Northwest, PLLC — Spokane, Washington, United States
• Institut de Rhumatologie de Montreal — Montreal, Quebec, Canada
• G.R.M.O. Inc — Québec, Quebec, Canada
• Artroscan s.r.o. — Ostrava, Czech Republic, Czechia
• Desert Medical Imaging — Indian Wells, California, United States

Full record on ClinicalTrials.gov

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