Study To Analyze Memory/Thinking Problems In Older Adults After Surgery

Completed

Conditions studied: Post-Operative Cognitive Decline in Older Adults

In brief

The purpose of the study is to examine specific neuroimaging predictors of memory and executive decline in older adults at various stages after total knee replacement surgery.

Key facts

Study ID

NCT01786577

Run by

University of Florida

People needed

147

Starts

2013-03-19

Expected to finish

2018-07-21

Last updated by the study team

2019-07-08

Who can join

Age: 60 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Planned total unilateral knee antroplasty or non-surgical knee osteoarthritis
• Age 60 years or older at the time of baseline assessment
• Telephone screening and in-person baseline cognitive testing not supportive of dementia
• Handedness: Right handed; restriction to left-right hemisphere laterality and white matter pathways
• Participant and family deny presence of difficulties with Instrumental Activities of Daily Living (IADL)
• All ethnic and racial groups will be recruited

You may not qualify if…

• Underlying medical diseases likely to limit lifespan or confound outcome analyses:
• cancer requiring treatment in past five years
• serious infectious diseases
• congestive heart failure
• chronic hepatitis
• history of organ transplantation
• seizure disorders
• history of head trauma resulting in intensive care
• current diagnosis of alcoholism, drug dependence, history of major tranquilizer use
• Neurodegenerative Exclusions:
• history of major stroke
• exposure to toxins or neuroleptics
• history of encephalitis
• neurological signs of upper motor neuron disease, cerebellar involvement, supranuclear palsy, or significant orthostatic hypertension
• signs of dementia.
• Psychiatric Exclusions:
• major psychiatric disorder
• major depression
• Conditions or behaviors likely to affect imaging or cognitive testing:
• claustrophobia
• non-medical bodily metal, pace-maker device
• less than five years of formal education
• inability to read or write
• self-reported hearing difficulty that interferes with standardized test administration

Where it is running

• University of Florida — Gainesville, Florida, United States

Full record on ClinicalTrials.gov

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