Circadian Phase in Bipolar Depression: Is it Delayed and Does it Normalize With Remission?

Completed

Conditions studied: Bipolar Disorder

In brief

The overall aim of this project is to compare sleep patterns and melatonin profiles in individuals with bipolar disorder during depression and after remission. The hypothesis is that sleep time, rest-activity cycles and melatonin onset will be delayed during depression and become less delayed after remission.

Key facts

Study ID

NCT01784341

Run by

Northwestern University

People needed

10

Starts

2011-08-01

Expected to finish

2016-12-01

Last updated by the study team

2017-03-28

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Ages between 18 and 55
• Bipolar Disorder Type I or II, with current major depression.
• Currently receiving active treatment from a psychiatrist for bipolar disorder

You may not qualify if…

• Recent history of, or current Diagnostic and Statistical Manual IV, Text Revision criteria for alcohol or substance abuse/dependence disorders
• circadian rhythm sleep disorders or sleep apnea
• current stimulant use
• any recent or planned transmeridian travel across more than two time zones
• recent, current, or planned shift work schedules
• pregnancy or plan to become pregnant
• a Young Mania Rating Scale Score of greater than or equal to seven
• received in the past two weeks or plan to receive bright light therapy, dawn simulation, sleep deprivation, or other forms of chronotherapy.

Where it is running

• Northwestern University — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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