Effects of b3-Adrenergic Receptor Agonists on Brown Adipose Tissue

Completed · Phase 2 · Has a placebo group

Conditions studied: Obesity

In brief

This study will test the hypothesis that human brown adipose tissue (BAT) can be activated using a β3-adrenergic receptor (AR) agonist. The efficacy of β3-AR agonist will be compared with cold exposure, which we have already shown can activate human BAT, as well as a placebo control.

Key facts

Study ID

NCT01783470

Run by

Aaron Cypess

People needed

15

Starts

2013-02-01

Expected to finish

2014-10-01

Last updated by the study team

2019-06-11

Who can join

Age: 18 and older, up to 65. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Healthy Male
• 18-65 years old
• BMI between 18-40
• Not participated in clinical trial and received either an investigational or marketed drug within two months prior to the study
• Not donated blood in previous two months

You may not qualify if…

• Women
• History of local or systemic infection disease with fever or requiring antibiotic within 4 weeks of drug administration
• Corrected QT interval above normal
• Laboratory test results that is more than 1.5 fold outside normal range and/or is judged to be clinically significant
• Current addition to alcohol or substances of abuse
• Mental incapacity, unwillingness or language barriers precluding adequate understanding or cooperation
• Use of system course of corticosteroids or other medication known to cause insulin resistance in previous 6 weeks
• Hyperthyroidism,hypothyroidism, hypertension (even if controlled with medications), heart disease (including CAD and CHF), cardiac arrhythmias, diabetes, unstable vasomotor system, or use of monoamine oxidase (MAO) inhibitors
• Diagnosis of bladder outlet obstruction or use of any medication to treat overactive bladder (e.g. Tolterodine, Solifenacin, Propiverine, Oxybutynin, and Fesoterodine)

Where it is running

• Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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