Lenalidomide/Bortezomib/Dexamethasone for Multiple Myeloma (MM)
Completed · Phase 2
Conditions studied: Multiple Myeloma
In brief
This research study is a Phase II clinical trial. Phase II clinical trials test the effectiveness of an investigational combination of drugs. The purpose is to learn whether the combination of drugs works in treating a specific cancer. "Investigational" means that the combination of drugs is still being studied. It also means that research doctors are trying to find out more about it. Examples of what they want to learn about are the safest dose to use, the side effects it may cause, and if the combination of drugs works for treating different types of cancer.
Key facts
- Study ID
- NCT01782963
- Run by
- Massachusetts General Hospital
- People needed
- 50
- Starts
- 2013-03-01
- Expected to finish
- 2017-12-01
- Last updated by the study team
- 2018-10-31
Who can join
Age: 60 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Documented symptomatic myeloma, with organ damage related to myeloma
- Myeloma that is measurable either by serum or urine evaluation of the monoclonal component or by assay of serum free light chains
- Must commit to complete abstinence from heterosexual contact or begin two acceptable method of birth control, one highly effective method and one additional effective (barrier) method
You may not qualify if…
- Eligible for autologous stem cell transplantation
- HIV positive on combination antiretroviral therapy
- Pregnant or breastfeeding
- Treated with any prior systemic therapy
- Primary amyloidosis or myeloma complicated by amyloidosis
- Receiving other investigational agents within 14 days of the start of this trial or during this trial
- Known brain metastases
- Poor tolerability or known allergy to any of the study drugs or similar compounds
- Intercurrent illness
- Previous history of another malignant condition except for basal cell carcinoma or stage I cervical cancer
- Inability to comply with an anti-thrombotic treatment regimen
- Peripheral neuropathy greater than or equal to grade 2
Where it is running
- John Hopkins University — Baltimore, Maryland, United States
- Massachusetts General Hospital — Boston, Massachusetts, United States
- Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States
- Brigham and Women's Hospital — Boston, Massachusetts, United States
- Dana-Farber Cancer Institute — Boston, Massachusetts, United States
- Massachusetts General Hospital/North Shore Cancer Center — Danvers, Massachusetts, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.