Effect of Steroids on Thrombosis (Blood Clot Formation) and Inflammation in Patients Undergoing Hip Surgery

Completed · Not applicable · Has a placebo group

Conditions studied: Total Hip Replacement

In brief

Studies have shown that surgery causes some reactions in your body consistent with inflammation. When the inflammation is extensive, it may affect different parts of the body including the lungs. Corticosteroids are commonly used to treat inflammation and are different from performance enhancing steroids associated with athletics. The purpose of this study is to determine the influence of low dose steroids given 3 times in a 24 hour period on thrombotic markers (markers that are associated with increased risks of clotting, a possible complication of surgery), interleukin (IL)-6 cytokine release (part of the stress response seen with surgery), and urine desmosine levels (a marker of lung injury) in a randomized placebo controlled trial patients undergoing total hip replacement.

Key facts

Study ID: NCT01782859
Run by: Hospital for Special Surgery, New York
People needed: 40
Starts: 2012-10-01
Expected to finish: 2014-01-01
Last updated by the study team: 2017-01-05

Who can join

Age: 50 and older, up to 90. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Patients undergoing unilateral total hip replacement with Drs. Douglas Padgett, Thomas Sculco, or Edwin Su.
Patients between the age of 50 and 90

You may not qualify if…

Patients on steroid therapy regardless of dose or duration of treatment or those requiring stress-dose steroids preoperatively
Patients who are smokers
Patients who have diabetes
Patients who are <50 and >90 years of age
Patients with history of prior difficulties tolerating corticosteroids

Where it is running

Hospital for Special Surgery — New York, New York, United States

Full record on ClinicalTrials.gov

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