Electronic Cigarettes and Reactivity to Smoking Cues

Running, not enrolling · Not applicable

Conditions studied: Nicotine Dependence

In brief

The purpose of this study is to determine whether electronic cigarettes can reduce reactivity to smoking-related cues.

Key facts

Study ID

NCT01782599

Run by

Mclean Hospital

People needed

125

Starts

2013-01-01

Expected to finish

2027-03-24

Last updated by the study team

2026-07-14

Who can join

Age: 18 and older, up to 45. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Provide written informed consent.
• Be aged 18-45.
• Report smoking cigarettes daily in the past 6 months.
• Have expired breath CO indicative of regular smoking.
• Have a score greater than 0 on the FTND.
• Be willing to use Nicotine Replacement Therapy (NRT) and the e-cigarette for a period of 2 to 3 weeks.
• Speak and read English.
• Pass an MRI safety screen and meet inclusion criteria for MRI scans.

You may not qualify if…

• Be pregnant (measured via urinalysis).
• Meet current abuse or dependence criteria for any substance other than nicotine or caffeine (measured via the SCID 5).
• Produce a positive urine screen for drugs of abuse or alcohol at the fMRI scan visits.
• Meet DSM-IV criteria for major depressive episode in the past six months, lifetime DSM-IV diagnosis of organic mental disorder, schizophrenia, schizoaffective disorder, bipolar disorder, delusional disorder or psychotic disorders not elsewhere classified (measured via the SCID 5).
• Be currently suicidal as assessed by DSM 5 and the Beck Depression Inventory.
• Current use of medications or any history of a medical condition that might affect the central nervous system at the time of scanning including: Abnormal structural MRI, or a history of head trauma or injury causing loss of consciousness lasting longer than 3 minutes or associated with skull fracture or intracranial bleeding or who had irremovable magnetically active objects on or within their body, history of epilepsy, current use of a beta-blocker or prescription analgesic/anxiolytic. (assessed by self-report).
• MRI exclusion criteria. (additional information outlined in the "protection of human subjects" section).
• History of claustrophobia.
• History of propylene glycol sensitivity/allergy.

Where it is running

• Mclean Hospital Imaging Center — Belmont, Massachusetts, United States

Full record on ClinicalTrials.gov

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