Development of a PET-MR Myocardial Perfusion Examination Using Regadenoson
Completed · Phase 4
Conditions studied: Ischemic Heart Disease
In brief
The objective for this pilot study is to develop an optimized, clinically usable myocardial PET-MR perfusion protocol and to determine which of all data potentially available should be acquired for a clinical myocardial perfusion examination. Hypothesis: The hypothesis is that high resolution, high sensitivity DCE MRI could replace the rest PET myocardial perfusion imaging, significantly decreasing examination time and patient radiation dose while maintaining the comprehensive reference-quality PET myocardial stress perfusion coverage. The primary outcome will be comparison of diagnostic accuracy of each combination of imaging to detect clinically significant coronary artery stenosis (≥70% diameter stenosis).
Key facts
- Study ID
- NCT01779869
- Run by
- Washington University School of Medicine
- People needed
- 16
- Starts
- 2013-01-01
- Expected to finish
- 2015-06-01
- Last updated by the study team
- 2018-06-15
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients who have had a clinically ordered rest/regadenoson single-isotope SPECT-MPI study within 10 days prior to cardiac PET-MRI examination
- Reversible perfusion abnormalities on SPECT imaging in at least 2 contiguous myocardial segments
- Patients for whom standard of care coronary ICA is planned
You may not qualify if…
- An clinical event (ie; worsening angina pectoris or myocardial infarction) occuring after the SPECT-MPI and before the cardiac MRI examination
- Myocardial revascularization occuring after the SPECT-MPI and before the cardiac MRI examination
- Contraindications to MR imaging (pacemaker, brain aneurysm clips, shrapnel, etc.)
- Renal insufficiency (GFR < 60 mL/min/1.73m2)
- Allergy or other contraindication to gadolinium-based MR contrast agent
- Second or third degree atrioventricular (AV) block
- Active asthma
- Seizures
- Current hypotension (<100/60)
- Current hypertension (>160/90)
- Pregnancy
- Breast feeding
- Use of caffeine, nicotine or over the counter cold medicines within 12 hours of the cardiac PET-MRI examination
- Use of the medication dipyridamole within 48 hrs of the cardiac PET-MRI examination
Where it is running
- Center for Clinical Imaging Research at Washington University School of Medicine — St Louis, Missouri, United States
Full record on ClinicalTrials.gov
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