AMD Phenotype and Genotype Study

Completed

Conditions studied: Age-Related Macular Degeneration, AMD

In brief

Background: \- Age-related macular degeneration (AMD) is a disease that blurs the sharp vision needed for activities such as reading, sewing, and driving. It affects the macula, the center of the retina at the back of the eye, which allows a person to see fine detail. Researchers want to collect medical histories, eye exam data, and genetic information that may be associated with AMD. They want to compare this information with information collected from people without AMD. Objectives: \- To collect medical information and gene samples for researchers studying AMD. Eligibility: * Individuals between and 60 and 90 years of age who have AMD in at least one eye. * Individuals between and 60 and 90 years of age who have no AMD in either eye. Design: * This study will involve one study visit. This study visit will last 6 to 8 hours. * Participants will have the following tests and exams as part of their study visit: * Full physical exam and medical history * Full eye examination * Laser scan of the eye * Retina function test * Vision sensitivity test * Optional blood sample (for genetic study) * No treatment will be provided as part of this study.

Key facts

Study ID

NCT01778491

Run by

National Eye Institute (NEI)

People needed

344

Starts

2012-11-05

Expected to finish

2015-09-29

Last updated by the study team

2018-04-05

Who can join

Age: 60 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• A participant is not eligible if any of the following exclusion criteria are present:
• Presence of lens or vitreous opacity in eye(s) with AMD to preclude adequate ophthalmic imaging
• Presence of ocular conditions that may now or in the future complicate the evaluation of AMD [e.g., vascular occlusion, diabetic retinopathy (>4 microaneurysms), etc.] in the eye(s) with AMD
• High myopia -6 Diopters or more severe
• Diagnosis of nystagmus
• Glaucoma with definite visual field defects. Participants with a history of the diagnosis of glaucoma, past or present use of medications to control intraocular pressure, or disc/nerve fiber layer defects suggestive of glaucoma can be eligible for the study if they have a documented normal Goldmann, Humphrey, or Octopus perimetry test within 6 months prior to qualification.

Where it is running

• National Institutes of Health Clinical Center, 9000 Rockville Pike — Bethesda, Maryland, United States
• University of Bonn — Bonn, Germany

Full record on ClinicalTrials.gov

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