Study of the Efficacy of Topical Nasal Steroids Patients With Nasal Polyps

Completed

Conditions studied: Size of Nasal Polyps, Control of Symptoms

In brief

Topical nasal steroid sprays are the mainstream treatment for patients with nasal polyps. Polyps tend to recur after surgery and topical nasal steroid sprays are used as the primary medical management to prevent continued growth. More recently high dose topical nasal steroid sprays are used. It is thought that the higher dose will penetrate the sinus cavities at an increased dose and will allow for greater control of polyp growth. Safety studies have been performed which have shown no suppression of the pituitary axis with long term high dose topical steroid or changes in intraocular pressure. However, studies in efficacy are limited despite their widespread use. The objective of this study will be to compare the effectiveness of two topical nasal steroid sprays in patients with recurrent nasal polyps.

Key facts

Study ID

NCT01777906

Run by

Loma Linda University

People needed

40

Starts

2013-02-01

Expected to finish

2017-02-01

Last updated by the study team

2017-03-27

Who can join

Age: 17 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects with nasal polyps who have had sinus surgery at least 3 months prior to enrollment.

You may not qualify if…

• Allergy to steroids
• Glaucoma
• Cataracts

Where it is running

• Sinus and Allergy Center — Loma Linda, California, United States

Full record on ClinicalTrials.gov

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