ECHELON-2: A Comparison of Brentuximab Vedotin and CHP With Standard-of-care CHOP in the Treatment of Patients With CD30-positive Mature T-cell Lymphomas

Completed · Phase 3

Conditions studied: Anaplastic Large-Cell Lymphoma, Non-Hodgkin Lymphoma, T-Cell Lymphoma

In brief

This is a double-blind, randomized, multicenter, phase 3 clinical trial to compare the efficacy and safety of brentuximab vedotin in combination with CHP with the standard-of-care CHOP in patients with CD30-positive mature T-cell lymphomas.

Key facts

Study ID

NCT01777152

Run by

Seagen Inc.

People needed

452

Starts

2013-01-31

Expected to finish

2020-10-02

Last updated by the study team

2021-11-30

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with newly diagnosed, CD30-positive mature T-cell lymphomas
• Fluorodeoxyglucose (FDG)-avid disease by PET and measurable disease of at least 1.5 cm by CT
• Eastern Cooperative Oncology Group (ECOG) performance status less than or equal to 2

You may not qualify if…

• History of another primary invasive malignancy that has not been in remission for at least 3 years
• Current diagnosis of primary cutaneous CD30-positive T-cell lymphoproliferative disorders and lymphomas or mycosis fungoides
• History of progressive multifocal leukoencephalopathy (PML)
• Cerebral/meningeal disease related to the underlying malignancy

Where it is running

• City of Hope National Medical Center — Duarte, California, United States
• Stanford Cancer Center — Stanford, California, United States
• Shands Cancer Center / University of Florida — Gainesville, Florida, United States
• Orlando Health, Inc. — Orlando, Florida, United States
• University of Illinois at Chicago — Chicago, Illinois, United States
• Cardinal Bernardin Cancer Center / Loyola University Medical Center — Maywood, Illinois, United States
• Holden Comprehensive Cancer Center / University of Iowa — Iowa City, Iowa, United States
• University of Kansas Cancer Center — Westwood, Kansas, United States
• Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States
• Dana Farber Cancer Institute — Boston, Massachusetts, United States
• Washington University School of Medicine — St Louis, Missouri, United States
• Memorial Sloan Kettering Cancer Center - Basking Ridge — Basking Ridge, New Jersey, United States
• Hackensack University Medical Center — Hackensack, New Jersey, United States
• Memorial Sloan Kettering Cancer Center - Commack — Commack, New York, United States
• Memorial Sloan Kettering Cancer Center — New York, New York, United States
• Columbia University Medical Center — New York, New York, United States
• Weill Cornell Medical College — New York, New York, United States
• James P. Wilmot Cancer Center / University of Rochester Medical Center — Rochester, New York, United States
• Albert Einstein Cancer Center — The Bronx, New York, United States
• Montefiore Medical Center — The Bronx, New York, United States
• Jewish Hospital, The — Cincinnati, Ohio, United States
• Cleveland Clinic, The — Cleveland, Ohio, United States
• Mercy Clinic Oncology — Oklahoma City, Oklahoma, United States
• Thomas Jefferson University — Philadelphia, Pennsylvania, United States
• Banner MD Anderson Cancer Center — Gilbert, Arizona, United States

Full record on ClinicalTrials.gov

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