Advanced Glycation End-products, Inflammation and Vascular Health in Chronic Kidney Disease
Completed · Not applicable
Conditions studied: Chronic Kidney Disease
In brief
The purpose of the study is to learn more about how advanced glycation end-products can affect insulin resistance, inflammation and blood vessel health in people with kidney disease.
Key facts
- Study ID
- NCT01769963
- Run by
- University of Alabama at Birmingham
- People needed
- 23
- Starts
- 2012-04-01
- Expected to finish
- 2014-02-01
- Last updated by the study team
- 2014-04-01
Who can join
Age: 19 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients with mild to moderate CKD (estimated glomerular filtration rate 15 - 59 ml/min/1.73m2).
You may not qualify if…
- Current or past use of anti-glycemic medications
- Fasting glucose > 126 mg/dl on screening visit or positive glucose on urine dipstick
- Nephrotic-range proteinuria (≥ 3.5 grams per day as assessed by a spot urine albumin to creatinine ratio obtained at the screening visit)
- Pregnancy or breast-feeding
- Clinical need for a specialized diet (low sodium, low potassium, etc.) or religious dietary restrictions.
- New or recent change (< 3 months) in dosage of medications known to affect vascular reactivity- angiotensin converting enzyme inhibitors, angiotensin II receptor blockers, beta-blockers, calcium channel blockers, HMG-CoA reductase inhibitors, etc.
- Current smoking or recent (< 6 months) cessation of smoking.
- Poorly controlled hypertension (≥ 140 mm Hg systolic or 90 mm Hg diastolic), or prior history of malignant hypertensive episode (SBP > 200) off of blood pressure medications.
- Participants with rapidly advancing renal failure.
- Severe anemia, defined as a hemoglobin < 8 g/dL for men and < 6 g/dL for women.
Where it is running
- University of Alabama — Birmingham, Alabama, United States
Full record on ClinicalTrials.gov
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