Improving Cancer Foci Detection in Prostate Cancer Using Multiparametric MRI/MRS
Withdrawn before enrolling
Conditions studied: Prostate Cancer
In brief
The investigators' goal is to develop a non-selective and non-invasive procedure to identify aggressive tumors and simultaneously identify their exact location in Prostate cancer patients undergoing radical prostatectomy by combining multiparametric MRI and machine learning techniques. The combination of multi-parametric MRI and machine learning (validated using histopathology) can lead to increased sensitivity and specificity of cancer foci in the prostate, and help in isolating aggressive from indolent tumors. This increased sensitivity and specificity may eventually lead to: a) a reduction in the number of patients that undergo unnecessary treatment, and b) enhance current treatment options by enabling the use of focused therapies. The investigators will recruit 15 patients with prostate cancer that are currently scheduled to undergo radical prostatectomy into the study. All patients will obtain an advanced MRI study prior to the radical prostatectomy. MRI scans will include a) high-resolution volumetric images using T1 and T2-weighted imaging, b) vascular images using dynamic contrast enhanced (DCE) imaging, c) biophysical microstructure images using diffusion-weighted imaging, and d) biochemical images using MR spectroscopic imaging. Following radical prostatectomy, a pathologist will grade the prostatectomy specimens based on standard of care (Gleason grading system). Correlations will be generated between the parameters obtained from scans and from clinical assessments.
Key facts
- Study ID
- NCT01766869
- Run by
- University of Maryland, Baltimore
- People needed
- 0
- Starts
- 2015-04-01
- Expected to finish
- 2015-04-01
- Last updated by the study team
- 2020-03-18
Who can join
Age: 18 and older. Sex: male. Healthy volunteers: not accepted.
You may qualify if…
- All male patients that have opted for radical prostatectomy
- Subjects must be capable of giving informed consent.
- Subjects must not be claustrophobic.
You may not qualify if…
- Subjects with pacemakers.
- Subjects who have metallic ferromagnetic implants or pumps.
- All females are excluded from this study.
- Subjects with kidney disease of any severity or on hemodialysis.
- Subjects with known allergies to gadolinium-based contrast agents.
- Subjects incapable of lying on their backs for up to an hour at a time.
Where it is running
- Ummc Msgcc — Baltimore, Maryland, United States
Full record on ClinicalTrials.gov
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