Safety and Efficacy Study of PRI-724 Plus Gemcitabine in Subjects With Advanced or Metastatic Pancreatic Adenocarcinoma

Completed · Phase 1

Conditions studied: Advanced Pancreatic Cancer, Metastatic Pancreatic Cancer, Pancreatic Adenocarcinoma

In brief

Laboratory studies suggest that the study drug may stop cancer cells from growing by affecting an interaction between proteins in the cells referred to as cAMP-response element-binding protein and ß-catenin. The purpose of this research study is to determine the highest safe dose of study drug that may be used when it is given together with a chemotherapy drug to patients with cancer of the pancreas.

Key facts

Study ID

NCT01764477

Run by

Prism Pharma Co., Ltd.

People needed

20

Starts

2013-04-01

Expected to finish

2015-10-01

Last updated by the study team

2017-08-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female patients, > 18 years of age.
• Patients with a documented (histologically- or cytologically-proven) epithelial cell/adenocarcinoma of the pancreas that is relapsed, locally advanced, or metastatic.
• Patients with measurable or evaluable disease according to the response evaluation criteria in solid tumors
• Patients eligible for second-line therapy after failing first-line therapy with the regimen FOLFIRINOX.
• Patients with a malignancy that is currently not amenable to surgical intervention, due to either medical contraindications or non-resectability of the tumor.
• Patients with a Karnofsky Performance Status of 70% to 100% (or equivalent, Eastern Cooperative Oncology Group [ECOG] performance status of 0 or 1); Performance Status Evaluation), and an anticipated life expectancy of ≥ 3 months.
• Patients, both male and female, who are either not of childbearing potential or who agree to use a medically effective method of contraception during the study and for 3 months after the last dose of study drug.
• Patients with the ability to understand and give written informed consent for participation in this trial, including all evaluations and procedures as specified by this protocol.

You may not qualify if…

• Women who are pregnant or lactating. Women of child-bearing potential (WOCBP) and fertile men with a WOCBP partner, not using adequate birth control.
• Patients with islet cell tumors or other non-epithelial cell malignancies of the pancreas.
• Patients with known CNS (or leptomeningeal) metastases not controlled by prior surgery or radiotherapy, or patients with symptoms suggesting CNS involvement for which treatment is required.
• Patients with an active second malignancy within the last 2 years with the exception of:
• Treated, non-melanoma skin cancers
• Treated CIS of the breast or cervix
• Controlled, superficial bladder carcinoma
• T1a or b prostate carcinoma involving < 5% of resected tissue and PSA within normal limits (WNL) since resection
• Patients with any of the following hematologic abnormalities at baseline:
• Hemoglobin < 9.0 g/dL
• Absolute neutrophil count (ANC) < 1,500 per mm3
• Platelet count < 100,000 per mm3
• Patients with any of the following serum chemistry abnormalities at baseline:
• Total bilirubin > 1.5× the ULN for the institution, unless considered due to Gilbert's Syndrome
• AST or ALT > 3× the ULN for the institution (> 5× ULN if due to hepatic involvement by tumor)
• Serum albumin < 2.5 g/dL
• Serum creatinine > 1.5× ULN (or a calculated creatinine clearance < 60 mL/min/1.73 m2)
• Patients with a significant cardiovascular disease or condition, including:
• Congestive heart failure (CHF) currently requiring therapy
• Need for anti-arrhythmic therapy for a ventricular arrhythmias
• Severe conduction disturbances
• Angina pectoris requiring therapy
• Left ventricular ejection fraction (LVEF) < 50% by MUGA or echocardiogram
• QTcF interval > 450 msec (males) or > 470 msec (females)
• Uncontrolled hypertension (per Investigator's discretion)

Where it is running

• USC Norris Comprehensive Cancer Center — Los Angeles, California, United States
• University of California, San Francisco — San Francisco, California, United States
• Massachusetts General Hospital Cancer Center — Boston, Massachusetts, United States
• Mayo Clinic — Rochester, Minnesota, United States
• University of Washington Seattle Cancer Care Alliance — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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