Physiologic Mechanisms in Pediatric Traumatic Brain Injury (TBI)

Completed

Conditions studied: Traumatic Brain Injury

In brief

The aims of this study explore the relationships between cerebral vasospasm, apolipoprotein-E (apo-E) genotype, physiologic symptoms, and neurocognitive outcomes that may either intensify or ameliorate secondary injury, for children with a traumatic brain injury. Exploring the apo-E genotype will help us know if injury response is altered in certain children and will aid in developing interventional approaches.

Key facts

Study ID

NCT01763892

Run by

Duke University

People needed

60

Starts

2012-12-01

Expected to finish

2015-09-01

Last updated by the study team

2015-10-20

Who can join

Age: 0 and older, up to 15. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• TBI patients admitted to the pediatric intensive care service (PICU)or pediatric progressive care unit
• Range in age from birth to 15 years
• TBI with a Glasgow Coma Scale of 3-15
• Acoustic window for adequate transcranial doppler (TCD) ultrasound
• English or Spanish speaking or understanding parent/legal guardian to consent
• Access for a buccal swab for genotyping

You may not qualify if…

• Non-English or Spanish speaking parents/legal guardian
• Children with a previously diagnosed neurodevelopmental delay

Where it is running

• Duke University Medical Center — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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