Taste Acuity and Caloric Intake After Acute Morphine Administration

Completed · Not applicable · Has a placebo group

Conditions studied: Taste Sweet, Taste Salty, Feeding Behavior

In brief

This study will investigate the effects of acute morphine administration on taste acuity and how much a person eats. It is hypothesized that there will be a dose dependent decrease in taste acuity and dose dependent increase in food intake associated with acute morphine administration. Knowledge from this study will impact the future of feeding behavior and obesity research in the general population. Results will also promote exploration of the long-term effect of opioid abuse on taste acuity and feeding behavior in substance abusing populations.

Key facts

Study ID

NCT01763697

Run by

Johns Hopkins University

People needed

36

Starts

2013-03-01

Expected to finish

2014-05-01

Last updated by the study team

2014-05-29

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy adult male and female volunteers
• Ages of 18 to 65

You may not qualify if…

• History of drug dependence (including opioid use disorders)
• History of taste dysfunction
• Significant medical or Axis I psychiatric disorder
• Any trauma or surgical procedures to the head or neck region
• Medication or illicit drug more than 4 out of the last 30 days.
• Pregnancy
• Abnormal electrocardiogram findings
• Negative rating of greater than 40% of the foods available for consumption

Where it is running

• Johns Hopkins Bayview Medical Center — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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