Functional Connectivity in Primary Focal Dystonia

Completed

Conditions studied: Dystonia

In brief

In this study we are looking at primary focal dystonias, including dystonias of the limbs, eyes, jaw or face, neck, and vocal chords. This study will use magnet resonance imaging (MRI) to see how the brain reacts while resting and doing a finger-tapping task. The investigators will test the hypothesis that disturbances in functional connectivity within the motor, affective and cognitive basal ganglia networks in primary focal dystonia (PFD) underlie the motor and non-motor symptoms in this disorder.

Key facts

Study ID

NCT01761903

Run by

University of Colorado, Denver

People needed

60

Starts

2012-05-01

Expected to finish

2018-06-01

Last updated by the study team

2019-11-01

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• English as their primary language
• Volunteers with PFD and healthy controls
• PFD volunteers must be on a stable dose of all dystonia and neuroactive drugs (e.g. antidepressants) for one month prior to enrollment
• PFD volunteers must not have been injected with botulinum toxin within the prior 2 months

You may not qualify if…

• Any contraindication to MRI scanning
• Any untreated neurological or psychiatric condition
• Evidence on neurological exam of any potentially confounding neurological disorder (e.g., Parkinson disease, Essential Tremor, etc.)
• Evidence of significant cognitive impairment (all subjects assessed using the Montreal Cognitive Assessment

Where it is running

• University of Colorado Denver — Aurora, Colorado, United States

Full record on ClinicalTrials.gov

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