Moderate Versus Aggressive Fluids for Acute Pancreatitis

Completed · Not applicable

Conditions studied: Pancreatitis

In brief

Fluid resuscitation for pancreatitis is recommended given evidence that hemoconcentration is associated with necrosis. However, there is insufficient evidence to support whether resuscitation should be moderate or aggressive. In this study the investigators aim to compare the clinical outcome associated with these strategies in a clinical randomized fashion to determine the optimal treatment of acute pancreatitis.

Key facts

Study ID

NCT01761539

Run by

University of Southern California

People needed

60

Starts

2013-04-01

Expected to finish

2015-11-01

Last updated by the study team

2016-08-02

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• mild to moderate pancreatitis

You may not qualify if…

• SIRS (2/4) a) HR >90 b) RR>20 or paCO2 <32 on room air c) T>100.4 F <96.8 F d) WBC >12, <4 or >10%
• severe pancreatitis
• renal insufficiency, Cr >2 mg/dl
• cardiac insufficiency
• respiratory insufficiency, O2 saturation <90% room air
• liver dysfunction, aklbumin <3mg/dL
• pregnancy
• hyponatremia, Na < 135meq/L
• clinical findings of volume overload peripheral edema ascites
• pancreatitis following endoscopic, radiographic, or surgical procedure

Where it is running

• Los Angeles County Hospital — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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