Evaluation of FeNO During and Following Acute COPD Exacerbation

Stopped early

Conditions studied: Chronic Obstructive Pulmonary Disease

In brief

The purpose of this research study is to determine whether exhaled nitric oxide (FeNO) goes up during an acute exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD) and whether the level of exhaled nitric oxide returns to normal in the weeks after an exacerbation.

Key facts

Study ID

NCT01761006

Run by

Wake Forest University

People needed

10

Starts

2013-03-01

Expected to finish

2014-09-23

Last updated by the study team

2017-11-07

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age: 40 years and above, inclusive
• Sex: Males and Females
• Smoking History: ≥20 pack years.
• COPD Defined as an FEV1/ FVC or FEV1/SVC ratio <70% predicted.
• AECOPD defined as a clinically significant worsening of COPD symptoms requiring treatment with antibiotics and/or systemic steroids and/or hospitalization for same.

You may not qualify if…

• Use of Systemic Corticosteroids for more than 48 hours prior to Visit 1.
• AECOPD requiring mechanical ventilation
• Study Participation Outside of This Protocol: Patients currently enrolled in studies of Investigational or non-Investigational Drugs or Medical Devices and/or who participated in these studies within 30 days prior to this study are excluded.

Where it is running

• Wake Forest University Baptist Medical Center — Winston-Salem, North Carolina, United States

Full record on ClinicalTrials.gov

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