Oral Antibiotics After 2-Stage Revision for Infected Total Hip Arthroplasty and Total Knee Arthroplasty

Completed · Not applicable

Conditions studied: Prosthesis-Related Infections

In brief

The primary purpose of this study is to compare the re-infection rates in patients undergoing 2-stage revision arthroplasty who receive additional oral antibiotic therapy to those patients who received in-hospital perioperative antibiotic only. Patients will be monitored for re-infection following hospital discharge, defined as deep infection of the joint space/capsule that requires return to the operating room within 24-months of the re-implantation procedure.

Key facts

Study ID

NCT01760863

Run by

Rush University Medical Center

People needed

185

Starts

2011-07-01

Expected to finish

2020-09-23

Last updated by the study team

2021-08-25

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients undergoing 2-stage revision arthroplasty of the knee or hip with the causative organism(s) identified using tissue culture and/or joint fluid analysis that is amenable to oral antibiotic therapy. Patients must be able to tolerate oral antibiotics and agree to participate in the study.

You may not qualify if…

• Patients with a fungal prosthetic joint infection, unable to tolerate or refuse to undergo oral antibiotic therapy, unable to follow-up at the specified intervals, allergic to the therapy of preference, or have an organism that is not amenable to oral antibiotic therapy.

Where it is running

• Rush University Medical Center — Chicago, Illinois, United States
• Central DuPage Hospital — Winfield, Illinois, United States
• Rothman Institute — Philadelphia, Pennsylvania, United States
• Vanderbilt — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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