Early Elimination of Premature Ventricular Contractions in Heart Failure

Stopped early · Not applicable

Conditions studied: Premature Ventricular Contractions, Congestive Heart Failure

In brief

Premature ventricular contractions (PVC) are a very common irregular heart beat (arrhythmias) even in patients without heart disease. Frequent PVCs are thought to occur in about 1-4% of the general population. Many patients with PVCs complain about skipping of their heart (palpitations), shortness of breath and feeling tired. In some patients PVCs may also result in weakening of the heart muscle (heart failure), which might be reversible with suppression of the PVCs.

Key facts

Study ID

NCT01757067

Run by

University of Maryland, Baltimore

People needed

3

Starts

2013-01-01

Expected to finish

2017-05-17

Last updated by the study team

2021-03-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with reduced ejection fraction (EF ≤45%) demonstrated by transthoracic echocardiogram and deemed to be non-ischemic by nuclear stress test or cardiac catheterization.
• Patients with >20% PVCs on 24 hour holter-recording
• Patient is 18 years of age or older
• Optimized medical therapy on stable therapy for minimum 3 months with no changes in beta-blocker, ACE-I/ARB, digoxin doses (varying diuretic doses permitted).

You may not qualify if…

• Patients who are under the age of 18 years of age
• Patients with >2 dominant PVC morphologies
• Patients with cardiac surgery in previous 3 months or scheduled for following 6 months
• Patients who were implanted with a biventricular device during the last three months or single/dual chamber device (with ventricular pacing >10%) during the last three months
• Significant symptoms associated with PVCs that would make favor immediate ablation
• Intracardiac mural thrombus or myxoma
• Pregnancy

Where it is running

• UCLA — Los Angeles, California, United States
• University of Maryland Medical Center — Baltimore, Maryland, United States
• University maryland medical Center — Baltimore, Maryland, United States
• Brigham and Women's Hospital — Boston, Massachusetts, United States
• University of Michigan — Ann Arbor, Michigan, United States
• Ohio State University — Columbus, Ohio, United States
• University of Pennsylvania — Philadelphia, Pennsylvania, United States
• University of Quebec — Sainte-Foy, Quebec, Canada

Full record on ClinicalTrials.gov

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