Study of Two Surgical Drilling Techniques to Treat Juvenile Osteochondritis Dissecans of the Knee

Completed · Not applicable

Conditions studied: Juvenile Osteochondritis Dissecans

In brief

The purpose of this study is to compare the functional, clinical and radiographic outcomes associated with trans-articular drilling versus retro-articular drilling, two commonly employed techniques of operative treatment for stable forms of juvenile osteochondritis dissecans (JOCD) lesions. This study also aims to better define the natural history of this condition in its most commonly identified pathological state (as a stable lesion) following surgical intervention by determining the rate of radiographic healing and any need for secondary surgery.

Key facts

Study ID

NCT01754298

Run by

Boston Children's Hospital

People needed

91

Starts

2013-01-18

Expected to finish

2020-10-16

Last updated by the study team

2020-12-03

Who can join

Age: 8 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of JOCD,
• Lesion located on the lateral aspect of the medial femoral condyle,
• Lesion considered stable based on MRI,
• Patient deemed skeletally immature based on MRI,
• Completed a course of conservative therapy.

You may not qualify if…

• Significant concomitant knee pathology (AVN, fracture, inflammatory arthritis, ACL tear, discoid/meniscal tear, etc.)
• Lesion healed sufficiently and surgery is not recommended,
• Prior surgery on the affected knee,
• Diagnosis of metabolic bone disorder (e.g. osteogenesis imperfecta),
• Diagnosis of sickle cell disease,
• History of prolonged corticosteroid or chemotherapy treatment,

Where it is running

• Kaiser Permanente Los Angeles — Los Angeles, California, United States
• Rady Children's Hospital — San Diego, California, United States
• Rocky Mountain Hospital for Children — Centennial, Colorado, United States
• Connecticut Children's Medical Center — Farmington, Connecticut, United States
• St. Luke's Children's Hospital — Boise, Idaho, United States
• Boston Children's Hospital — Boston, Massachusetts, United States
• Washington University School of Medicine — St Louis, Missouri, United States
• Hospital for Special Surgery — New York, New York, United States
• Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States
• Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States
• University of Pennsylvania — Philadelphia, Pennsylvania, United States
• Tennessee Orthopaedic Alliance — Nashville, Tennessee, United States
• Medical College of Wisconsin — Milwaukee, Wisconsin, United States
• The Hospital for Sick Children — Toronto, Ontario, Canada

Full record on ClinicalTrials.gov

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