Estimating Apnea Phenotypes From Polysomnography: Oxygen

Completed · Not applicable · Has a placebo group

Conditions studied: Sleep Apnea

In brief

This study seeks to employ advanced methods to estimate the individual factors contributing to sleep apnea from standard recordings made during routine clinical sleep studies. This study focuses on breathing control or "loop gain" as one of the factors contributing to sleep apnea. Increased levels of oxygen in the air is known to make breathing more stable by lowering "loop gain". Here, our goal is to use a new method capable of detecting a reduction in loop gain with oxygen. The investigators also aim to test whether a high loop gain measured at baseline/placebo predicts a greater improvement in sleep apnea with oxygen therapy.

Key facts

Study ID

NCT01751971

Run by

Brigham and Women's Hospital

People needed

47

Starts

2012-11-01

Expected to finish

2016-07-01

Last updated by the study team

2018-03-20

Who can join

Age: 20 and older, up to 79. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Apnea/hypopnea index >20 events per hour
• Age 20-79 years

You may not qualify if…

• COPD with desaturation (resting SpO2<96%)
• Use of respiratory stimulants or depressants
• Pregnancy

Where it is running

• Brigham and Women's Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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