Sonoelastography: Ultrasound Method to Measure Liver Fibrosis

Completed · Not applicable

Conditions studied: Chronic Liver Disease, Non-Alcoholic Fatty Liver Disease, Hepatitis C Virus (HCV) Coinfection, Hepatitis B Virus (HBV), Drug-Induced Liver Injury

In brief

HYPOTHESIS: The investigators hypothesize that sonoelastography (SE) will provide accurate quantitative measurements that can be used to stage liver fibrosis in patients with chronic liver disease. 1. To measure liver stiffness with sonoelastography in adults with suspect diffuse liver disease who will undergo non-focal liver biopsy as part of their routine clinical care 2. To assess the sensitivity and specificity of sonoelastography for the detection and staging of liver fibrosis 3. To evaluate the effect of steatosis and inflammation on the estimation of liver fibrosis using sonoelastography

Key facts

Study ID

NCT01747772

Run by

Massachusetts General Hospital

People needed

180

Starts

2010-02-01

Expected to finish

2014-02-14

Last updated by the study team

2017-06-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients (age 18 or older)
• Men or women
• Suspected diffuse liver disease
• Consent to participate in the study

You may not qualify if…

• Pregnancy
• Acute illness/cognitive impairment resulting in inability to cooperate with ultrasound.
• Patients that do not consent to ultrasound or sonoelastography.

Where it is running

• Massachusetts General Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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