Safety and Efficacy Study of Gevokizumab to Treat Non-infectious Uveitis Controlled With Systemic Treatment

Stopped early · Phase 3 · Has a placebo group

Conditions studied: Uveitis

In brief

The purpose of this study is to evaluate the efficacy of gevokizumab in reducing the risk of recurrent uveitic disease in subjects with non-infectious uveitis whose disease is currently controlled with systemic treatment.

Key facts

Study ID

NCT01747538

Run by

XOMA (US) LLC

People needed

281

Starts

2012-10-01

Last updated by the study team

2016-07-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of non-infectious intermediate, posterior, or pan- uveitis in at least one eye
• Controlled uveitic disease in both eyes
• Stable dose of oral corticosteroids in combination with selected stable immunosuppressive therapy
• Effective contraceptive measures

You may not qualify if…

• Infectious uveitis and masquerade syndromes
• Isolated anterior uveitis
• Contraindication to mydriatics
• Active tuberculosis disease
• History of allergic or anaphylactic reactions to monoclonal antibodies
• History of recurrent infection or predisposition to infection; active ocular infection
• Pregnant or nursing women
• Other protocol-defined inclusion/exclusion criteria may apply

Where it is running

• Study site — Phoenix, Arizona, United States
• Study site — Beverly Hills, California, United States
• Study site — Los Angeles, California, United States
• Study site — Redlands, California, United States
• Study site — Sacramento, California, United States
• Study site — San Luis Obispo, California, United States
• Study site — Santa Ana, California, United States
• Study site — Victorville, California, United States
• Study site — Golden, Colorado, United States
• Study site — Littleton, Colorado, United States
• Study site — Bridgeport, Connecticut, United States
• Study site — Washington D.C., District of Columbia, United States
• Study site — Lakeland, Florida, United States
• Study site — St. Petersburg, Florida, United States
• Study site — Tampa, Florida, United States
• Study site — Atlanta, Georgia, United States
• Study site — Chicago, Illinois, United States
• Study site — Indianapolis, Indiana, United States
• Study site — Iowa City, Iowa, United States
• Study site — Ellsworth, Maine, United States
• Study site — Baltimore, Maryland, United States
• Study site — Cambridge, Massachusetts, United States
• Study site — Waltham, Massachusetts, United States
• Study site — Detroit, Michigan, United States
• Study site — Chandler, Arizona, United States

Full record on ClinicalTrials.gov

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