Effects of Transcranial Magnetic Stimulation on Object Recognition

Completed · Not applicable · Has a placebo group

Conditions studied: Repetitive TMS (rTMS), Sham rTMS, Bilateral rTMS, Unilateral rTMS

In brief

Background: \- The brain has natural rhythms called brain waves. An electroencephalogram (EEG) can record these rhythms. When people identify the picture of a familiar object shown on a computer screen, the communication between certain regions of the brain increases. An EEG can detect these communication brain waves. Transcranial magnetic stimulation (TMS) can affect these brain waves by slightly changing the brain s rhythms. Researchers want to see if changing brain rhythms with TMS interferes with the ability to identify pictures of familiar objects. This study will provide more information about how TMS can affect brain waves and behavior. Objectives: \- To see if TMS can interfere with the brain s ability to identify pictures of familiar objects. Eligibility: \- Healthy volunteers between 18 and 70 years of age. Design: * This study requires two visits to the clinical center. The first visit will last about 2 hours. The second visit will last about 4 hours. * Participants will be screened with a physical exam and medical history. * At the first visit, participants will have an object recognition test. Participants will look at pictures of several objects on a computer screen. They will then have to state whether the objects they see on the screen are familiar. The object recognition test will be done along with TMS. * At the second visit, participants will have an EEG while taking the object recognition test. Brain waves will be monitored during the test. They will then repeat the test while having repetitive TMS to study its effect on object recognition. The participants will then take the object recognition test alone for a final time. This will make sure that TMS effects (if any) on the ability to identify familiar object images are no longer present.

Key facts

Study ID

NCT01747200

Run by

National Institute of Neurological Disorders and Stroke (NINDS)

People needed

13

Starts

2012-11-16

Expected to finish

2017-01-26

Last updated by the study team

2017-07-02

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may not qualify if…

• Presence of cardiac pacemaker, brain stimulator, shrapnel, surgical metal, clips in the brain, cochlear implants, metal fragments in the eye.
• Pregnancy or lactation.
• History of any serious medical illness or hearing problems
• Intake of medication that affect the central nervous system like anti depressants, antihistamines, antipsychotics, dopamine agonists, benzodiazepines and antiepileptics in the past 3 months.
• Presence of neurological or psychiatric illnesses like brain tumor, migraine, depression, bipolar disorder, schizophrenia.
• History of any seizure.
• Use or abuse of any drug in the past 6 months or intake of more than 7 alcoholic drinks a week in females and more than 14 alcoholic drinks a week in males.
• Exclusion criteria specific for MRI::
• Presence of metal in the body, such as a cardiac pacemaker, brain stimulator, shrapnel, surgical metal, clips in the brain or on blood vessels, cochlear implants, artificial heart valves or metal fragments in the eye as these make having an MRI unsafe.
• Presence of metallic dental fillings which are likely to cause MRI artifacts
• Uncomfortable being in a small space for up to 2 hours.
• Unable to lie flat on the back for up to 2 hours

Where it is running

• National Institutes of Health Clinical Center, 9000 Rockville Pike — Bethesda, Maryland, United States

Full record on ClinicalTrials.gov

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