Glycerin Suppositories to Reduce Jaundice in Premature Infants
Completed · Not applicable
Conditions studied: Idiopathic Hyperbilirubinemia, Neonatal Hyperbilirubinemia, Prematurity
In brief
The purpose of this study is to find out if giving glycerin suppositories will help decrease the length of time premature infants need phototherapy. The investigators hypothesize that glycerin suppositories (initiated along with phototherapy) will have no effect on reducing duration of phototherapy in premature infants with jaundice.
Key facts
- Study ID
- NCT01746511
- Run by
- University of Rochester
- People needed
- 79
- Starts
- 2012-07-01
- Expected to finish
- 2013-09-01
- Last updated by the study team
- 2015-12-09
Who can join
Age: 1 and older, up to 1. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Baby born between 30 to 34 6/7 weeks gestational age (GA) at birth and admitted to NICU
- Baby with physiologic hyperbilirubinemia requiring phototherapy by current NICU criteria.
- Parental permission.
You may not qualify if…
- Babies less than 30 weeks GA or greater than 34 6/7 weeks GA
- Non-physiologic hyperbilirubinemia: (1) positive Coombs test and (2) hematocrit < 5th percentile for GA (see Jopling J, Henry E, Wiedmeier SE, Christensen RD, Reference. Ranges for Hematocrit and Blood Hemoglobin Concentration During the Neonatal Period: Data From a Multihospital Health Care System. Pediatrics 2009; 123(2):e333 -e337.) and (3) ABO or Rh incompatibility.
- Any infant with bilirubin level within 2 mg/dL of exchange transfusion.
- Any infant who has phototherapy started prior to reaching light level (prophylactic)
- Baby with any GI abnormalities such as NEC, intestinal perforation, gastroschisis, omphalocele, malrotation and or volvulus, duodenal atresia, intestinal strictures/adhesions, imperforate anus.
- Any infant begun on triple or greater phototherapy at time of initiation of treatment.
- Any infant judged by the attending physician to be placed at increased risk by study participation.
Where it is running
- University of Rochester Medical Center NICU — Rochester, New York, United States
Full record on ClinicalTrials.gov
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