Effect of Vitamin D Supplementation on Endothelial Function in Obese Adolescents

Completed · Phase 1

Conditions studied: Obesity, Endothelial Dysfunction, Vitamin D Deficiency

In brief

Vitamin D deficiency has been linked to endothelial dysfunction in adults. Obese adolescents have a high prevalence of Vitamin D deficiency as well as evidence of endothelial dysfunction. Our hypothesis is that supplementation of Vitamin D deficient adolescents with Vitamin D would lead to improvement in endothelial dysfunction.

Key facts

Study ID

NCT01746264

Run by

Mayo Clinic

People needed

19

Starts

2012-11-01

Expected to finish

2013-12-01

Last updated by the study team

2016-05-02

Who can join

Age: 12 and older, up to 18. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 12-18 years
• BMI >95% for age and gender
• 25 (OH) D levels less than 30 ng/ml

You may not qualify if…

• 25 (OH) D levels >30 ng/mL
• Serum calcium >10.4 mg/dL
• Serum phosphorus > 4.7 mg/dl
• Pregnancy or nursing
• Current cancer
• Patients on vitamin D3 supplementation exceeding 400 IU/day
• Hypertension defined as Blood Pressure over the 95th percentile for age, gender and height
• Dietary calcium intake exceeding 1500 mg/day
• Hepatic or renal disorders
• Type 1 or type 2 diabetes mellitus
• Subjects receiving insulin, metformin, or oral hypoglycemic medications
• Subjects with malabsorption disorders (celiac disease, cystic fibrosis, inflammatory bowel disease)

Where it is running

• Mayo Clinic — Rochester, Minnesota, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.