Sex Differences, Hormones & Smoking Cessation

Completed · Not applicable · Has a placebo group

Conditions studied: Tobacco Cessation

In brief

Data suggest that progesterone may improve smoking cessation outcomes perhaps by reducing impulsive behavior. However, the clinical literature on this topic is lacking. Therefore, in Project I we are proposing a double-blind randomized controlled trial to assess the role of exogenous progesterone on impulsivity and smoking cessation in a sample of males and females who are motivated to quit smoking.

Key facts

Study ID

NCT01744574

Run by

University of Minnesota

People needed

216

Starts

2012-12-01

Expected to finish

2017-07-27

Last updated by the study team

2019-07-12

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male 18 to 60 years old
• Female 18 to 50 years old
• Self-report regular smoking
• Motivated to quit smoking
• In stable physical/mental health
• Self report of regular menstrual cycles (female only)
• English fluency
• Understand the study procedures and able to provide informed consent
• Ability to participate fully in research elements for the duration of the trial.

You may not qualify if…

• Current or recent (< 3 months) breastfeeding (females only)
• Current or planned pregnancy within the next three months (females only)
• Conditions contraindicated to progesterone treatment.

Where it is running

• Delaware Clinical Research Unit, University of Minnesota — Minneapolis, Minnesota, United States

Full record on ClinicalTrials.gov

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