Study to See if Platelet Transfusion Stop or Lessen the Effect of the Drug on Platelets

Completed · Phase 1

Conditions studied: Inhibition on Platelet Aggregation

In brief

Study to see if platelet transfusion stop or lessen the effect of the drug on platelets

Key facts

Study ID

NCT01744288

Run by

AstraZeneca

People needed

258

Starts

2012-12-01

Expected to finish

2014-04-01

Last updated by the study team

2014-04-24

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Provision of signed and dated, written informed consent prior to any study specific procedures
• Healthy male and/or female volunteers aged 18 to 50 years, inclusive, with suitable veins for cannulation or repeated venipuncture. (Healthy as determined by medical history and physical examination, laboratory parameters, electrocardiogram (ECG) perform
• Have a body mass index (BMI) between 18 and 35 kg/m2 (inclusive) and weigh at least 50 kg and no more than 120 kg

You may not qualify if…

• ADP induced platelet aggregation <60% prior to platelet apheresis
• History of peptic ulcer disease Healthy volunteers with a propensity to bleed (eg, due to recent trauma, recent surgery, active or recent gastrointestinal bleeding or moderate hepatic impairment)
• Any clinically significant illness, medical/surgical procedure or trauma within 4 weeks of the first administration of the investigational product
• Current smokers, those who have smoked or used nicotine products within the previous 3 months and those who tested positive for cotinine at screening or at admission to the study center

Where it is running

• Research Site — Overland Park, Kansas, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.