Dose of Corticosteroids in COPD
Stopped early · Phase 4
Conditions studied: COPD
In brief
COPD (chronic obstructive pulmonary disease) is a long-lasting lung disease usually caused by long-term smoking. COPD can get worse, making people sick enough to need hospitalization. Corticosteroids are very effective and are almost always used, but nobody knows the right dose. High doses may work better but could cause more side effects than low doses. Typical treatment lengths last at least one week. This study will be comparing two common regimens: either 40mg of corticosteroids daily (low dose), or 80mg of corticosteroids daily (high dose). It is unknown which regimen works better..
Key facts
- Study ID
- NCT01742338
- Run by
- Rutgers, The State University of New Jersey
- People needed
- 89
- Starts
- 2012-05-03
- Expected to finish
- 2020-03-15
- Last updated by the study team
- 2024-04-10
Who can join
Age: 40 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- i. Patients with a diagnosis of COPD, emphysema, or chronic bronchitis ii. Age ≥ 40 years-old iii. Smoking history ≥ 10 pack-years iv. Presentation to the emergency room with increased dyspnea, increased sputum, or increased cough v. Admission to the hospital
You may not qualify if…
- i. Alternative diagnosis for cause of dyspnea, increased sputum or cough ii. Patients who requires intubation at time of recruitment iii. Patients who are unable to give consent iv. Patients who are pregnant or could be pregnant or are currently breast-feeding v. Women of child-bearing age who cannot use methods of contraception as described in the consent, including condoms, female condoms, cervical caps, diaphragms, and intra uterine devices.
- vi. Patients who were previously entered into the trial and are re-admitted to the hospital with a new COPD exacerbation.
Where it is running
- Robert Wood Johnson University Hospital — New Brunswick, New Jersey, United States
- University Medical Center at Princeton — Plainsboro, New Jersey, United States
Full record on ClinicalTrials.gov
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