Diet and Whole-body Vibration Training on Cardiovascular and Autonomic Function
Completed · Not applicable
Conditions studied: Obesity, Pre-hypertension, Hypertension
In brief
Obesity is a major risk factor for premature arterial abnormalities including high blood pressure and increased stiffness. Previous studies have shown that weight loss via lifestyle modifications is associated with a decrease in large artery (aorta) stiffness. However, along with decreases in fat mass, hypocaloric diet reduces muscle mass. Whole body vibration results in similar increases in muscle mass and strength than those observed after resistance exercise and is feasible for special populations such as the obese and the elderly. The investigators hypothesis is that weight loss via diet combined with whole body vibration training would additively reduce arterial stiffness and blood pressure in obese women. The investigators also hypothesize that the improved arterial function with weight loss would be associated with beneficial changes in the main mechanisms involved in BP regulation.
Key facts
- Study ID
- NCT01741779
- Run by
- Florida State University
- People needed
- 60
- Starts
- 2011-09-01
- Expected to finish
- 2012-04-01
- Last updated by the study team
- 2012-12-05
Who can join
Age: 45 and older, up to 65. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- Female
- 45 to 65 years of age
- At least 1 year after menopause
- Body mass index of 27-39.9
- Sedentary or low active (less than 2 hr per wk)
You may not qualify if…
- Younger than 45 or older than 65 years of age
- Body mass index lower than 27, or 40 or higher
- Physically active or competitively active
- Smoker
- Use of hormone replacement therapy of less than 1 yr
- Use of calcium channel blocker or beta blockers
- Use dietary supplementations (e.g.,L-arginine,L-citrulline,antioxidants)
- Uncontrolled diabetes
- Any restriction that would significantly interfere with compliance with the diet (e.g., allergy to nuts or dairy, or need to avoid soy)
Where it is running
- Florida State University — Tallahassee, Florida, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.