Treatment of Symptoms After Stent Placement for Urinary Tract Obstruction
Completed · Phase 4 · Has a placebo group
Conditions studied: Ureteral Obstruction
In brief
The purpose of this study is to determine whether combination therapy with Tolterodine ER and Tamsulosin is more effective than monotherapy with tamsulosin alone in reducing stent symptoms. The second purpose is to determine if people have less stent discomfort if they take these medications starting 2 weeks before the stent is placed The investigators hope to show that the addition of Tolterodine ER to Tamsulosin will provide added benefits in reducing stent symptoms in patients who have had unilateral placement of a ureteral stent.
Key facts
- Study ID
- NCT01741454
- Run by
- University of Wisconsin, Madison
- People needed
- 181
- Starts
- 2012-11-01
- Expected to finish
- 2018-03-30
- Last updated by the study team
- 2019-07-10
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients with unilateral ureteral stent placement for urolithiasis
You may not qualify if…
- Pre-existing lower urinary tract symptoms
- Active urinary tract infection
- Contraindication to anticholinergic medication
- Prior hypersensitivity or allergy to tolterodine
- Patients with severe hepatic impairment (Child-Pugh Class C)
- Patients with uncontrolled close (narrow) angle glaucoma
- Patients with urinary retention
- Current anticholinergic use
- Chronic pelvic pain syndromes (e.g. acute/chronic prostatitis, interstitial cystitis)
- Women who are pregnant or nursing
- Under 18 years of age
- Prior hypersensitivity or allergy to tolterodine
- Patients with severe hepatic impairment (Child-Pugh Class C)
- Patients with uncontrolled close (narrow) angle glaucoma
- Patients with urinary retention
- Unable to provide informed consent
Where it is running
- University of Wisconsin — Madison, Wisconsin, United States
Full record on ClinicalTrials.gov
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