Neuroimaging Studies of Chronic Primary Headaches Using Positron Emission Tomography and Magnetic Resonance Imaging

Completed

Conditions studied: Migraine, Chronic Migraine

In brief

Investigators hypothesize that chronic primary headaches are accompanied by a discrete pattern of brain metabolism and activity involving brain structures related to the development of acute exacerbations as well as pain modulation. Such structures include the brainstem, hypothalamus, and orbitofrontal cortex and can be defined using functional brain imaging.

Key facts

Study ID

NCT01741246

Run by

University of California, San Francisco

People needed

78

Starts

2011-09-01

Expected to finish

2015-06-01

Last updated by the study team

2015-06-30

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients aged 18-65
• No medical contraindication.
• Chronic headache group:
• Patients with chronic primary headaches who are experiencing phases with background pain as well as habitual pain exacerbations.
• Able to provide informed consent.
• Not pregnant or planning to become so, with a pregnancy test prior to scanning.
• Control group and Episodic migraine group:
• Patients with episodic migraine
• Able to provide informed consent.
• Not pregnant or planning to become so, with a pregnancy test prior to scanning.

You may not qualify if…

• Taking a migraine preventive currently or in the last fifteen days.
• Known claustrophobia
• Patient is pregnant, planning to be pregnant, or becomes pregnant.
• Patients with metal implants.
• Patients who have had a study involving radiation within the one year prior to enrolling in this study

Where it is running

• UCSF — San Francisco, California, United States

Full record on ClinicalTrials.gov

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