GLOBAL Clinical Study

Status unconfirmed

Conditions studied: Coronary Artery Disease

In brief

The GLOBAL study is an international multi-center, prospective study designed to enroll up to 10,000 consecutive eligible subjects who are clinically referred for coronary CT angiography for assessment of suspected coronary artery disease (CAD). The purpose of the study is to perform extensive biomarker analysis of atherosclerosis in patients phenotyped using advanced imaging modalities of atherosclerosis.

Key facts

Study ID

NCT01738828

Run by

Global Genomics Group, LLC

People needed

10000

Starts

2012-12-01

Expected to finish

2016-12-01

Last updated by the study team

2016-02-09

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Ages 18-90
• Caucasian and of Non-Hispanic or Non-Latino origin
• Referral for coronary CT angiography to evaluate for presence of CAD
• The patient has signed the appropriate Institutional Review Board approved Informed Consent Form

You may not qualify if…

• Immunosuppressive or immunomodulatory therapy including any dose of systemic corticosteroids in the preceding 30 days (except if steroids are administered as pre-medication prior to contrast administration for CT scan within 24 hours).
• Chemotherapy in the preceding year
• Major surgery in the preceding 2 months
• Blood or blood product transfusion in the preceding 2 months
• Subjects for whom coronary CT angiography is contraindicated per institutional standard of care
• Subjects with previous coronary arterial revascularization (PCI or CABG)
• Subjects with atrial fibrillation/flutter or frequent irregular or rapid heart rhythms, which occurred within the past 3 months
• Subjects with a pacemaker or implantable cardioverter-defibrillator implant
• Active congestive heart failure or the presence of known non-ischemic cardiomyopathy
• Known genetic disorders of atherosclerosis, lipid or lipoprotein metabolism

Where it is running

• Heart Center Research — Huntsville, Alabama, United States
• The University of Arizona — Tucson, Arizona, United States
• Sutter Roseville Medical Center — Roseville, California, United States
• Colorado Health Medical Group — Colorado Springs, Colorado, United States
• The MedStar Heart Research Institute — Washington D.C., District of Columbia, United States
• Elite Research and Clinical Trials — Miami Beach, Florida, United States
• Georgia Regents University — Augusta, Georgia, United States
• University of Chicago — Chicago, Illinois, United States
• Iowa Heart Center — West Des Moines, Iowa, United States
• Baton Rouge General Medical Center — Baton Rouge, Louisiana, United States
• Walter Reed National Military Medical Center — Bethesda, Maryland, United States
• Detroit Clinical Research Center — Farmington Hills, Michigan, United States
• William Beaumont Hospital — Royal Oak, Michigan, United States
• Minneapolis Heart Institute Foundation — Minneapolis, Minnesota, United States
• University of Minnesota — Minneapolis, Minnesota, United States
• United Heart and Vascular Center — Saint Paul, Minnesota, United States
• Midwest Heart and Vascular Specialists — Kansas City, Missouri, United States
• Saint Luke's Lipid and Diabetes Research Center — Kansas City, Missouri, United States
• Long Island Heart Associates — Mineloa, New York, United States
• St. Francis Hospital — Roslyn, New York, United States
• Zwanger Pesiri Radiology — Stony Brook, New York, United States
• Sentral Clinical Research Services — Cincinnati, Ohio, United States
• The Linder Center for Research & Education at The Christ Hospital — Cincinnati, Ohio, United States
• University of Cincinnati Physicians Company — Cincinnati, Ohio, United States
• Ohio Health Research Institute — Columbus, Ohio, United States

Full record on ClinicalTrials.gov

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