Inhaled Nitrous Oxide and Labor Analgesia

Stopped early · Phase 2

Conditions studied: Labor Pain

In brief

Hypothesis: The administration of nitrous oxide for labor analgesia will decrease the labor epidural anesthesia rate by 15%. Specific Aim: To determine if nitrous oxide can be an effective alternative technique for the provision of labor analgesia at Magee-Womens Hospital.

Key facts

Study ID

NCT01738672

Run by

Ya'aqov Abrams

People needed

16

Starts

2012-02-01

Expected to finish

2013-10-01

Last updated by the study team

2017-11-21

Who can join

Age: 14 and older. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• all women of childbearing age (including children aged 14 years and above)who are pregnant
• parturients who request labor analgesia of family medicine investigators certified in the use of nitrous oxide for labor analgesia at Magee-Women's Hospital
• informed verbal and written consent

You may not qualify if…

• coexisting medical conditions that are contraindications to the use of nitrous oxide (i.e. recent eye or ear surgery, history of Meniere's disease, history of vitamin B-12 deficiency)
• history of severe nausea and vomiting
• history of chronic pain
• inability to hold a facemask
• impairment of consciousness or intoxication at time of delivery
• received intravenous opioids within two hours prior to initiation of nitrous oxide
• impaired oxygenation (ex: lung cysts, pneumothorax, pulmonary hypertension, or pulmonary edema) with a room-air pulse oximetry reading less than 95%
• hemodynamic instability
• non-reassuring fetal heart rate tracing
• inability to read, write and understand the English language enough to complete all survey questionnaires and pain assessment scales.

Where it is running

• Magee-Womens Hospital — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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