Mechanisms of Pharyngeal Collapse in Sleep Apnea, Study C

Withdrawn before enrolling · Not applicable

Conditions studied: Sleep Apnea

In brief

In obstructive sleep apnea (OSA), the upper airway recurrently closes during sleep. The mechanisms that lead to airway closure are not completely understood. Models to study mechanisms of airway collapse have been proposed. However, these models have not been tested in the human upper airway. Gas density and viscosity are different gas properties that influence upper airway collapse and are variables of different models. In this study, subjects will breathe gas mixtures of different densities and viscosities for brief periods of time in order to test those models.

Key facts

Study ID

NCT01738022

Run by

Brigham and Women's Hospital

People needed

0

Starts

2012-12-08

Expected to finish

2017-02-07

Last updated by the study team

2019-07-11

Who can join

Age: 21 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Normal subjects or patients with OSA

You may not qualify if…

• Any unstable cardiac condition (other than well controlled hypertension) or pulmonary problems.
• Any medication known to influence breathing, sleep/arousal or muscle physiology
• Concurrent sleep disorders (insomnia, narcolepsy, central sleep apnea or parasomnia)
• Claustrophobia
• Inability to sleep supine
• Allergy to lidocaine or oxymetazoline hydrochloride
• For women: Pregnancy

Where it is running

• Brigham and Women's Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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