Catheter Resistance Monitoring to Predict Catheter-Associated Adverse Events in Children and Adolescents
Completed
Conditions studied: Cancer, Hematologic Disorders
In brief
Catheter occlusion and dysfunction are common complications of central venous access device (CVAD) use in children with cancer and hematologic disorders. These events can lead to interruption of therapy and may require device removal and replacement. Attempts to clear occlusion can cause device fracture. There is a clear link between catheter occlusion and other serious complications including bloodstream infection and intravascular thrombosis. There is evidence that catheter occlusion or dysfunction may be preceded by subclinical catheter narrowing, which could be detected by accurate measurement of catheter resistance. This study aims to observe and describe the feasibility and results of catheter resistance monitoring (CRM) over time with the aim of prospectively identifying patients at high risk of catheter occlusion. If CRM is feasible and proves to be sensitive and specific, it could provide an opportunity for preemptive therapy to prevent occlusion, which might also prevent bloodstream infection or thrombosis.
Key facts
- Study ID
- NCT01737554
- Run by
- St. Jude Children's Research Hospital
- People needed
- 10
- Starts
- 2012-12-01
- Expected to finish
- 2016-09-01
- Last updated by the study team
- 2016-12-21
Who can join
Age: 5 and older, up to 24. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Receiving treatment for any disease at St. Jude Children's Research Hospital (SJCRH).
- Age ≥5 years to <25 years.
- Participant is using either a single or double lumen tunneled CVAD (ports will not be eligible) as part of standard clinical care.
- Participant anticipates being present weekly at SJCRH for at least 12 weeks
You may not qualify if…
- Plan to remove CVAD within 12 weeks.
- Expected survival less than 12 weeks
- Past enrollment in the CaRMA study or past catheter resistance monitoring
Where it is running
- St. Jude Children's Research Hospital — Memphis, Tennessee, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.