Developing Anesthesia as Post Traumatic Stress Disorder (PTSD) Therapy

Status unconfirmed · Phase 1 · Has a placebo group

Conditions studied: Healthy

In brief

This preclinical phase 1 development study in healthy volunteers seeks to identify if low doses of commonly used non-triggering anesthetic agents might have clinical utility for modulating emotional memory processing and to understand the nature of the brain mechanisms of drug action. Optimally, a drug, dose and brain mechanism of action will be identified that will form the foundation for future use in clinical studies of patients with PTSD.

Key facts

Study ID

NCT01736020

Run by

Southern California Institute for Research and Education

People needed

293

Starts

2009-09-01

Expected to finish

2017-04-01

Last updated by the study team

2016-10-13

Who can join

Age: 18 and older, up to 35. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy adults.
• Between the ages of 18 and 35.

You may not qualify if…

• Pregnancy.
• Left-handed.
• Unusual facial anatomy.
• History of esophageal reflux.
• Respiratory problems.
• Central nervous system disorders.
• Cardiovascular problems.
• Kidney disease.
• Diabetes.
• History of Substance abuse.
• History of adverse anesthetic reactions.
• Hepatitis.
• Failure to pass MRI screening questionnaire.
• Fear of small-enclosed spaces.
• Mental illness.
• Non-native English speakers.

Where it is running

• University of California, Irvine — Irvine, California, United States

Full record on ClinicalTrials.gov

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