Mechanisms of Pharyngeal Collapse in Sleep Apnea, Study D

Withdrawn before enrolling · Not applicable

Conditions studied: Sleep Apnea

In brief

In obstructive sleep apnea (OSA), the upper airway recurrently closes during sleep. The mechanisms that lead to airway closure are not completely understood. Some studies have shown that there is progressive narrowing of the pharyngeal airway across breaths during expiration (Progressive Expiratory Narrowing, PEN) preceding an obstructive apnea. The investigators will assess the viscoelastic properties of the pharyngeal airway and its role in PEN.

Key facts

Study ID

NCT01733784

Run by

Brigham and Women's Hospital

People needed

0

Starts

2012-12-08

Expected to finish

2017-02-07

Last updated by the study team

2019-07-11

Who can join

Age: 21 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Normal subjects or patients with OSA

You may not qualify if…

• Any unstable cardiac condition (other than well controlled hypertension) or pulmonary problems.
• Any medication known to influence breathing, sleep/arousal or muscle physiology
• Concurrent sleep disorders (insomnia, narcolepsy, central sleep apnea or parasomnia)
• Claustrophobia
• Inability to sleep supine
• Allergy to lidocaine or oxymetazoline hydrochloride
• For women: Pregnancy

Where it is running

• Brigham and Women's Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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