A Study of the Effect of Arterial Carbon Dioxide Tension on the Recovery of Spontaneous Respiration

Completed · Not applicable

Conditions studied: Surgery, Anesthesia

In brief

The investigators data reveal an important new observation regarding the recovery of breathing during emergence from general anesthesia: respiration resumes as a prolonged abdominal expiration event. The present study aims to further clarify the physiology of recovery of breathing with the addition of a cutaneous monitor for arterial carbon dioxide measurement and a comparison of two different recovery paradigms.

Key facts

Study ID

NCT01733446

Run by

University of Pennsylvania

People needed

50

Starts

2012-09-01

Expected to finish

2018-02-01

Last updated by the study team

2018-04-23

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or Female patients ages > 18 to < 80
• Scheduled for procedures under general anesthesia with jet ventilation
• Sign informed consent
• Candidate for total intravenous anesthesia with propofol and remifentanil (which is standard protocol in this type of population)

You may not qualify if…

• Absence of informed consent
• No planned use intra-operative use of jet ventilation
• Known difficulties with jet ventilation during prior surgical procedures
• Emergency surgery
• Baseline (oxygen saturation)SpO2 <92% on room air
• BMI > 50
• Pregnant or lactating females
• Skin damage, rash or significant lesions in the areas covered by the RIP bands or transcutaneous CO2 sensor.

Where it is running

• University of Pennsylvania — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.