A Phase 1 Study of MM-141 in Patients With Advanced Solid Tumors

Completed · Phase 1

Conditions studied: Hepatocellular Carcinoma

In brief

This study is a Phase 1 and pharmacologic open-labeled dose-escalation trial using a "3+3" design, evaluating MM-141 at varying dose levels and frequencies.

Key facts

Study ID

NCT01733004

Run by

Merrimack Pharmaceuticals

People needed

42

Starts

2012-11-01

Last updated by the study team

2016-08-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Advanced malignant solid tumors for which no curative therapy exists that has recurred or pgrogressed following standard therapy
• Eighteen years of age or above
• Able to understand and sign an informed consent (or have a legal representative who is able to do so)
• Measurable disease according to RECIST v1.1
• ECOG Performance Score of 0 or 1
• Adequate bone marrow, hepatic, renal and cardiac function
• Willing to abstain from sexual intercourse or to use an effective form of contraception during the study and for 90 days following the last dose of MM-141

You may not qualify if…

• Active infection or fever > 38.5°C during screening visits or on the first scheduled day of dosing
• Symptomatic CNS disease
• Received other recent antitumor therapy
• Pregnant or breast feeding

Where it is running

• Study site — Marietta, Georgia, United States
• Study site — Boston, Massachusetts, United States
• Study site — Detroit, Michigan, United States
• Study site — Villejuif, France

Full record on ClinicalTrials.gov

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