The Acute and Chronic Effects of Fruit Polyphenols on Chronic Disease (PPF)
Completed · Not applicable · Has a placebo group
Conditions studied: Nutritional and Metabolic Disease, Overweight
In brief
1. The primary objective is to determine the effect of fruit polyphenols on postprandial lipoprotein triglyceride metabolism after consumption a standard high carbohydrate/fat breakfast meal with a beverage rich in fruit-derived polyphenols compared to energy and macro-/micro-nutrient matched control beverage (acute, Part 1). 2. Secondary objectives are: 1)to assess the effects of consuming daily for 8 weeks (chronic, Part 2) a beverage rich in fruit polyphenols compared to an energy and macro-/micro- nutrient matched control beverage on fasting glucose, insulin, lipids and markers of oxidative stress; and 2) to assess the effects of these beverages on meal-related changes in metabolic and oxidative stress measures after 8 weeks daily consumption.
Key facts
- Study ID
- NCT01729949
- Run by
- Clinical Nutrition Research Center, Illinois Institute of Technology
- People needed
- 34
- Starts
- 2012-12-01
- Expected to finish
- 2018-06-26
- Last updated by the study team
- 2021-07-27
Who can join
Age: 40 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Non-smoking healthy overweight or class I obesity adult men and women
- Age 40-65yr
- Weight stable
- Able to provide informed consent
- Able to comply and perform the procedures requested by the protocol.
You may not qualify if…
- Smokers or recent past smokers
- Men or women with known or suspected intolerance or hypersensitivity to the study materials (or closely related compounds) or any of their stated ingredients
- Diabetes
- Fasting blood glucose concentrations >125 mg/dL
- Fasting Total Cholesterol >250 mg/dL (6.47mmol/L)
- Fasting Triglycerides >250 mg/dL (2.82 mmol/L)
- Fasting LDL cholesterol >180 mg/dL (4.66 mmol/L)
- Uncontrolled blood pressure >140 mmHg/90 mmHg
- Documented vascular disease
- Cancer other than skin (non-melanoma) in previous 5 years
- Lactating and/or pregnant
- Taking medications or dietary supplements eg., antioxidant supplements, lipid lowering medication, blood pressure lowering medications.
- Recent blood donors (within 3 months)
- Vegans
- Substance (alcohol or drug) abuser (within the last 2 years)
- Participated in a chronic feeding or medication clinical trial in the last 3 months.
- Excessive coffee and tea consumers (> 4 cups/d)
Where it is running
- Clinical Nutrition Research Center — Chicago, Illinois, United States
Full record on ClinicalTrials.gov
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