Venous Thromboembolic Prophylaxis After Trauma: Three Times a Day Unfractionated Heparin Versus Twice a Day Enoxaparin

Completed · Phase 4

Conditions studied: Venous Thromboembolic Disease, Deep Vein Thrombosis, Pulmonary Embolism

In brief

The rate of venous thromboembolic events in trauma patients at high risk for deep vein thrombosis and pulmonary embolism receiving low dose unfractionated heparin every 8 hours will be equivalent or less than a similar group of patients given a standard every 12 hour dose of low molecular weight heparin.

Key facts

Study ID

NCT01729559

Run by

Scripps Health

People needed

495

Starts

2012-11-01

Expected to finish

2014-10-01

Last updated by the study team

2016-07-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Admitted to Scripps Mercy Trauma Service
• ≥18 Years old
• Stratified to either Significant or Highest risk of VTE by ACCP guidelines

You may not qualify if…

• Estimated Injury Severity Score (ISS) ≤9
• Likely to be discharged before hospital day 7
• Systemic coagulopathy defined with an International Normalized Ratio (INR) of ≥1.2
• Body Mass Index (BMI) >40
• Likely to Survive for <7 Days
• Pregnancy
• Evidence of renal insufficiency (Cr ≥1.3)
• Delayed transfer to this facility (>24 hrs)
• Prisoners

Where it is running

• Scripps Mercy Hospital — San Diego, California, United States

Full record on ClinicalTrials.gov

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